Phosphoamide
Phosphoramide is a chemical compound with the molecular formula O=P(NH2)3. It is a derivative of phosphoric acid in which each of the hydroxyl groups have been replaced with an amino group. Phosphoramide arises from the reaction of phosphoryl chloride with ammonia. It is a white solid that is soluble in polar … See more Phosphoramide is also the parent compound for a range of derivatives called phosphoramides. An example compound is the polar solvent hexamethylphosphoramide (HMPA). See more • Media related to phosphoramides at Wikimedia Commons • The dictionary definition of phosphoramide at Wiktionary See more WebSelect search scope, currently: articles+ all catalog, articles, website, & more in one search; catalog books, media & more in the Stanford Libraries' collections; articles+ journal articles & other e-resources
Phosphoamide
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WebPhosphoramide mustard C4H11Cl2N2O2P - PubChem Apologies, we are having some trouble retrieving data from our servers... PUGVIEW FETCH ERROR: 403 Forbidden National Center for Biotechnology Information … WebDiethyl phosphoramidate C4H12NO3P - PubChem Apologies, we are having some trouble retrieving data from our servers... PUGVIEW FETCH ERROR: 403 Forbidden National Center for Biotechnology Information …
WebJul 4, 2024 · The phosphoramide metabolite forms cross-linkages within and between adjacent DNA strands at the guanine N-7 position. These modifications are permanent and eventually lead to programmed cell death. Acrolein has no antitumor activity but is the principal-agent responsible for the manifestation of hemorrhagic cystitis. WebPhosphoramidates are the aliphatic amides of phosphoric acid and are widely employed in the synthesis of differentially protected phosphate esters as more stable alternatives to halophosphates.88 They have been used as prodrug moieties to enhance water solubility 89 and to enhance the therapeutic potential of a parent drug. 90 In addition, they …
WebPhosphoramides DrugBank Online Phosphoramides Name Phosphoramides Accession Number DBCAT000952 Description Amide derivatives of phosphoric acid such as compounds that include the phosphoric triamide (P (=O) (N) (N) (N)) structure. Drugs Drugs & … WebMar 18, 2024 · Phosphoramidate bonds are nevertheless found in the natural world, e.g., in ligase adenylyl-lysine intermediates (12). The absence of an NP-DNA polymerase presents a severe obstacle to studying the informational and functional aspects of this polymer.
WebThe relative alkylating activities of two of the cytotoxic metabolites of cyclophosphamide, phosphoramide mustard and nornitrogen mustard, have been studied at pH 4.6 and 7.4. The products formed on alkylation of ethanethiol by these metabolites have
WebAbstract. The reaction pathway of alkylating agents is often exploited in the design of bifunctional anti-cancer drugs. These drugs form mono-DNA adducts as well as inter- and intra-strand cross-linked adducts, notably by reaction at DNA bases, including the N-7-position of guanine (G). A positive-ion fast-atom bombardment (FAB) mass spectrum ... phishing synonymeWebphosphoramide noun any derivative of phosphoric acid in which each hydroxy group has been replaced with an amino or substituted amino group; P(=O)(NR) How to pronounce … phishing symbol outlookWebApr 7, 2014 · CYCLOPHOSPHAMIDE Used in the treatment of WBC cancers (AML/ALL) and Lymphoma Cell Cycle – Non specific Alkylating agent Adds Alkyl group (CnH2n+1) to DNA. 3. CYCLOPHOSPHAMIDE Mechanism of Action • the main effect of cyclophosphamide is due to its metabolite Phosphoramide mustard • Phosphoramide mustard forms DNA … tsr eye coatsWebHexamethylphosphoramide 99% Synonym (s): HMPA, Hexamethylphosphoric acid triamide, Tris (dimethylamino)phosphine oxide Linear Formula: [ (CH3)2N]3PO CAS Number: 680 … phishing tackle reviewsWebPhosphonamides (1.2.6) that have a chlorine group on the distance of five carbon atoms easily form piperidine ring when t-BuOK in dimethylformamide (DMF) is used as a base … phishing tabletop exercise templateWebAll the CWMPHs exhibit pH-sensitive water swellability and degradability at room temperature, so that they show a higher water swelling ratio and faster degradation under acidic conditions via an activated cleavage of P–O and P–N bonds. tsrexplorerWebAbstract. The reaction pathway of alkylating agents is often exploited in the design of bifunctional anti-cancer drugs. These drugs form mono-DNA adducts as well as inter- and … phishing tackle ltd