Hipk2 relocalization
WebbCytoplasmic relocalization of HIPK2 induced by HMGA1 overexpression is a mechanism of inactivation of p53 apoptotic function that the authors believe to be novel. High-mobility group A1 (HMGA1) overexpression and gene rearrangement are frequent events in … Webb1 jan. 2024 · HIPK2 expression and activity are tightly regulated by post-translational modifications and microRNAs (miRNAs), and its functions strongly depend on the cellular context and on its subcellular localization, which can be nuclear and/or cytoplasmic …
Hipk2 relocalization
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WebbHIPK2 is an evolutionarily conserved serine/threonine kinase. 3. , 4. It mainly localizes in subnuclear speckles, and only a small proportion is found in the nucleoplasm or cytosol. 5. HIPK2 comprises an N -terminal region containing a sumoylation site at Lysine 25 6. , 7. Webb15 mars 2024 · There were three expression patterns of HIPK2 including positive nucleus, positive both nucleus and cytoplasm, and only positive cytoplasm. The main positive location of normal epithelium cells...
Webb1 feb. 2013 · Here we show that HIPK2 autophosphorylates its activation loop residues Y354 and S357. Each of these two residues controls kinase activity, substrate affinity and localization of the kinase, thus suggesting a means of how activation loop … Webb1 nov. 2013 · Hence, cytoplasmic relocalization of HIPK2 induced by HMGA1 overexpression is a mechanism of inactivation of p53 apoptotic function that we believe to be novel. Authors. Giovanna Maria Pierantoni, Cinzia Rinaldo, Marcella Mottolese, …
Webb30 juni 2010 · Here, we show that Bcl-2 is a gene regulated by the HMGA1-p53-HIPK2 complex and that HMGA1 is able to abolish the repression promoted by p53 on Bcl-2 expression. Subsequently, we looked for other components of this multiprotein … Webb4 apr. 2024 · HIPK2 is a serine/threonine kinase, located in the nucleus, that was initially found to be able to phosphorylate p53 at Ser46 to promote apoptosis; it has been widely studied. It has been reported that HIPK2 can simultaneously regulate TGF-β/Smad3, Wnt/β-catenin, Notch and NF-κB pathways in the kidney to initiate inflammation and …
WebbHomeodomain-interacting protein kinase 2 (HIPK2) is a tumor suppressor mediating growth suppression and apoptosis upon genotoxic stress through phosphorylation of p53 at Ser46. Here we show that Src phosphorylates HIPK2 and changes its subcellular localization. Using mass spectrometry we identified 9 Src-mediated Tyr-phosphorylation …
Homeodomain-interacting protein kinase 2 is an enzyme that in humans is encoded by the HIPK2 gene. HIPK2 can be categorized as a Serine/Threonine Protein kinase, specifically one that interacts with homeodomain transcription factors. It belongs to a family of protein kinases known as the DYRK kinases. Within this family HIPK2 belongs to a group of homeodomain-interacting prote… shoreline plaza guilford ctWebbHence, cytoplasmic relocalization of HIPK2 induced by HMGA1 overexpression is a mechanism of inactivation of p53 apoptotic function that we believe to be novel . Other interactions of HIPK2 In response to DNA damage , depletion of HIPK2 by RNA … sandringham road post officeWebbHIPK2 relocalization from the nucleus to the cytoplasm, in- In contrast, in neoplastically transformed cells as well as in hibiting p53 apoptotic function, whereas HIPK2 overexpres- embryonic cells, the constitutive expression of HMGA pro- sion re-established HIPK2 … shoreline plastics snap jacketWebb1 feb. 2011 · HIPK2 functions as a general regulator of gene expression but also as a kinase that phosphorylates and regulates transcription factors such as p53 and IPF1/PDX (insulin promoter factor-1/pancreatic duodenal homeobox-1) [12], [13], [14]. sandringham road post office cleethorpesWebb1 apr. 2014 · The intracellular localization of HIPK2 can be regulated by acetylation of lysines contained in NLS1 (de la Vega et al., 2012) or by cytoplasmic relocalization of HIPK2 by increased expression of high-mobility group A1 protein (Pierantoni et al., … shoreline plumbing and heating plymouth maWebb21 mars 2024 · HIPK2 is a target for SENP1 desumoylation regulated by the cytoplasmic-nuclear shuttling of SENP1. HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function. HIPK2 participates in the TGF-beta … shoreline plaza apartments boiseWebboverexpression, HIPK2 cytoplasmic localization, and low spontaneous apoptosis index (comparable to that observed in mutant p53–carrying tumors) was observed in WT p53–expressing human breast carcinomas. Hence, cytoplasmic relocalization of HIPK2 induced by HMGA1 overexpression is a mechanism of inactiva- sandringham road school doncaster