WebOct 2, 2014 · Quetiapine is an atypical antipsychotic, used clinically in the treatment of schizophrenia, acute mania in bipolar disorders, and bipolar depression in adults. In this study, the effect of green tea extracts (GTE) on the pharmacokinetics of quetiapine (substrate of CYP3A4) was investigated in rats. Male Wistar albino rats received GTE … WebDec 16, 2011 · Cytochrome P450 3A4 substrates: Green tea extract inhibits CYP3A4 and can affect the intracellular concentration of drugs metabolized by this enzyme.[12] UGT …
Inhibitory Effects of Eight Green Tea Catechins on …
WebGreen tea is used worldwide. Different dietary supplements and beverages are prepared from green tea extracts. Various in vitro and in vivo studies involving human intestinal and hepatic microsomes have revealed the inhibitory effect of green tea on CYP3A4 [ 105 ], resulting in the significantly increased AUC of simvastatin compared with ... WebJul 15, 2024 · In vitro study results have suggested potential interactions, whereas human clinical trials have not found any effects on the major metabolic enzymes CYP2D6 and … fnf kaity icon
Isolation, analysis and in vitro assessment of CYP3A4 inhibition by ...
WebJan 1, 2007 · We conducted this clinical study to determine the effect of repeated green tea catechin administration on human cytochrome P450 (CYP) enzyme activities. Forty-two healthy volunteers underwent a 4 ... WebMethylxanthines, purine alkaloids found in plants, are found in beverages (coffee, tea, cocoa) and foods (chocolate and other cocoa-containing foods) commonly consumed worldwide. Members of this family include caffeine, theophylline and theobromine. Methylxanthines have a variety of pharmacological effects, and caffeine and theophylline … WebSep 10, 2009 · Catechins, the main polyphenol constituents of green tea, inhibited the activity of the isoforms 3A4, 2A6, 2C19, and 2E1 whereas they increased the activity of … fnf kaity mod