Danish 82c trial

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August undefined, 2024

WebTrial Oversight. The Danish Study to Assess the Efficacy of ICDs in Patients with Non-ischemic Systolic Heart Failure on Mortality (DANISH) was an investigator-initiated multicenter, randomized ... WebNov 1, 2001 · On the heels of those influential papers, Dr. Marie Overgaard et al. has published another Danish trial regarding the benefits of RT on survival in high risk …

Postmastectomy radiation therapy in locally advanced breast …

WebAug 28, 2016 · Principal Findings: The primary outcome, incidence of all-cause mortality, occurred in 21.6% of the ICD group versus 23.4% of the control group (p = 0.28). Younger patients (<59 years) appeared to derive greater benefit from ICD implantation versus older patients (p for interaction = 0.009). Sudden cardiac death: 4.3% versus 8.2%; … WebMay 15, 1999 · Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomised trial. Author links open overlay panel Dr Marie Overgaard MD a, Maj-Britt Jensen MSc c, Jens Overgaard MD b, Per S Hansen MD f, ... chs to bos

LANDMARK TRIALS IN BREAST CANCER - SlideShare

WebNov 15, 2001 · By comparison, in the Danish 82c trial, 33% of patients had ≥4 nodes involved (2). For postmastectomy patients treated on randomized trials who received chemotherapy without radiotherapy, the LRF rates for patients with 1–3 and ≥4 lymph nodes were 6–33% and 14–46%, respectively (34). WebApr 9, 2024 · 乳腺癌改良根治术后放疗靶区勾画.ppt WebFeb 10, 2015 · Supporting this concern, we noticed that the CSS curves diverge very early for the high-risk patient group, whereas in the Danish 82c trial, which enrolled patients with higher risk of breast cancer, the survival benefit from RT was not appeared until 5 years after treatment.15 The early divergence of the CSS curves in our high-risk subgroup ... chs to bermuda

Post-Mastectomy Adjuvant Radiotherapy (PMRT) SpringerLink

Postmastectomy Radiation Therapy for Lymph Node …

WebMay 15, 1999 · Postoperative radiotherapy decreased the risk of locoregional recurrence and was associated with improved survival in high-risk postmenopausal breast-cancer … WebDec 5, 2024 · Apart from menopausal status, the DBCG 77B and 82C trials had identical selection criteria, but while 77B trial used classic CMF with oral cyclophosphamide a … chs to bostonWebSep 11, 2013 · The Danish group also undertook a study in high risk postmenopausal patients. Specifically, in the Danish 82c trial randomized 1460 postmenopausal patients younger than 70 years of age after total mastectomy and axillary dissection, to postmastectomy radiation therapy in addition to tamoxifen for one year or tamoxifen alone . descriptive analysis on titanic dataset

"WebThe role of postmastectomy irradiation together with systemic treatment was evaluated in high-risk patients included in the Danish Breast Cancer Cooperative Group (DBCG) protocol 82. As of June 1989, a total of 1473 pre- and menopausal patients were randomized to postmastectomy irradiation + CMF ver … " - Danish 82c trial

Danish 82c trial

Breast Cancer - Locally Advanced - Rad Onc Clinicals

WebJun 11, 2024 · An increase in the actuarial risk of ischemic heart disease was not seen in the analysis of the Danish Breast Cancer Group trials 82b and 82c, in which more than 3,000 patients were followed (5) . These data have led Kurtz to note the potential hazard of thoracic irradiation and to highlight the importance of radiotherapy technique in breast ... WebThe Danish 82c trial randomized 1,375 high-risk postmenopausal women who underwent total mastectomy with partial axillary node dissection to tamoxifen alone or tamoxifen …

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Weband overall survival rate. The Danish 82b trial noted an improvement in overall survival at 10 years (54% versus 45%, P <.001) in premenopausal women with high-risk disease who had received CMF (cyclophos-phamide, methotrexate, fluorouracil) chemotherapy, whereas the Danish 82c trial noted a somewhat simi-lar improvement in postmenopausal women ... WebApr 13, 2004 · As well, in the Danish 82c trial, 1 year of tamoxifen therapy was used, as opposed to the current standard of 5 years of tamoxifen therapy. In the Danish 82b trial and the British Columbia trial, CMF chemotherapy was used,5, 6 as opposed to anthracycline chemotherapy currently in common use.42

WebThe March 82C is an open-wheel race car, designed by and built by March Engineering, to compete in the 1982 IndyCar season.The March chassis won 5 out of the 11 races that … WebMay 8, 2014 · The Danish 82b trial demonstrated the use of PMRT, in conjunction with systemic chemotherapy, reduced local failure (LF) by 23 % and improved diseasefree survival (DFS) and OS by 14 % and 9 %, respectively. 7 In the Danish 82c trial the use of PMRT, in addition to hormonal therapy, reduced LF by 27 % and improved OS by 9 %.8 …

WebAug 1, 2006 · (1999) Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomised trial. Lancet 353: 1641–1648

WebIn Postmenopausal Danish Trial 82c, as in Premenopausal Danish Trial 82b, inadequate surgical Tx of the axilla resulted in a median of only 7 axillary LNs removed at surgery. A suboptimal duration of tamoxifen was also employed (1 yr vs. the typical 5 yrs).

Webadjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomised trial. Lancet 1999; 353: 1641–48. 2 Overgaard M, Hansen PS, Overgaard J, et a l. … chs to baliWebThe Danish 82b and 82c trials were included node-negative patients who were eligible for this trial due to the presence of high-risk factors as invasion of pectoralis muscle or skin … chs to bos flight statusWebThe trial protocol, available at NEJM.org, was approved by the regional scientific ethics committee for the Capital Region of Denmark and the Danish Data Protection Agency. The trial was performed ... descriptive analysis and thematic analysisWebJul 2, 2024 · In this trial, 318 premenopausal women with high-risk breast cancer were randomized to mastectomy and chemotherapy or chemotherapy plus RT. Patients in the radiation arm exhibited a reduction in 10-year LRR, as in the DBCCG trials. The Danish 82c trial studied the effect of PMRT in high-risk postmenopausal women using a similar … chs to bos flightsWebApr 17, 2010 · A subgroup analysis of the Danish 82b and 82c trials suggests that the proportional survival benefit from improved local control actually varies among women … chs to boston flightsWebDec 3, 2024 · Ultimately, the DANISH trial suggests that routine ICD therapy for all patients with symptomatic ischemic cardiomyopathy with ≤35% may not result in the strong … chs to bna directWebJan 12, 2024 · NSABP-B06 (1976–1980) 25-Year follow-up of a randomized trial of 590, 632, and 629 patients treated with mastectomy, lumpectomy alone, or lumpectomy followed by adjuvant RT Cumulative incidence of … chstoday