Cisplatin ld50 in mice

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August undefined, 2024

WebSynergism of cisplatin-oleanolic acid co-loaded calcium carbonate nanoparticles on hepatocellular carcinoma cells for enhanced apoptosis and reduced hepatotoxicity ... HCC is still a highly lethal disease. 3 Hepatic resection and liver transplantation provide good treatment that ... Kunming mice were obtained from the Animal Care Facility ... WebAug 14, 2024 · The vehicle control mice were injected with normal saline (cisplatin group) or corn oil (AAI group). After collecting the blood and urine samples from each mouse, the levels of nephrotoxic...

Determination of LPS LD50 in C57BL/6 mice. The mice were …

WebDec 21, 2024 · Mice were divided into a control group, cisplatin-treated group, and cisplatin + myo-inositol-treated group, which were treated with cisplatin or myo-inositol accordingly. Mice received intraperitoneal injection of cisplatin at a dose of 25 mg/kg, and they were sacrificed by cervical dislocation three days later. WebAug 6, 2024 · The mice in cisplatin groups were intraperitoneally administered (2 mg/kg cisplatin dissolved in 0.9% saline) with 0.1 ml of cisplatin. The mice in the normal control (NC) group were intraperitoneally injected with physiological saline. The … high waisted coloured skinny jeans

C57BL/6 mice require a higher dose of cisplatin to induce …

WebHowever, the immune tolerance limits the effect of chemotherapeutic drugs. Therefore, the mechanism of cisplatin in promoting PD-L1 expression by YAP1 was investigated in the present study, and we found that cisplatin increased the expression level of YAP1 in the mouse liver with H22 cells. WebApr 13, 2024 · Head and neck squamous cell carcinoma (HNSCC) is among the most severe and complex malignant diseases with a high level of heterogeneity and, as a result, a wide range of therapeutic responses ... WebNude mice were divided into 3 groups (etoposide, cisplatin and MTX-group), 7 to 9 per group and received drug treatment which started when their tumor grew to 100 approximately 300 mm3 in volume. All drugs were intraperitoneally administrated to nude mice (each drug: 1/4 mouse LD50 dose X3, weekly). high waisted comfortable pants

SAFETY DATA SHEET Product Name: Cisplatin Injection 1.

STANDARD OPERATING PROCEDURE #715 USE OF …

WebOct 1, 2024 · In addition, significant immune cell infiltration was observed in the kidney after four doses of 9 mg/kg cisplatin, contrary to what has been previously reported. These results indicate that multiple strains of mice can be used with our repeated low-dose … WebMaterial Name: Cisplatin Solution for Injection - 0.5 and 1 mg/ml Revision date: 02-Jan-2007 Page 3 of 7 Version: 1.1 7. HANDLING AND STORAGE ... Rat Oral LD50 3000 mg/kg Sodium chloride Eye Irritation Rabbit Moderate Mouse Oral LD 50 4000 mg/kg Mouse Oral LD 50 32.7 mg/kg ... high waisted colour popWebcisplatin can be used to cause renal dysfunction as an approach to mimic human serum levels of renally excreted drugs. We aimed to determine the dose of cisplatin that did not affect the survival rate of mice and to achieve human-like serum concentrations of … how many fccla members does virginia have

"WebApr 25, 2014 · Cisplatin (dichlorodiamino platinum) is an inorganic platinum-based chemotherapeutic agent that is widely used in the treatment of a variety of solid malignant tumors such as head and neck, lung, testis, ovarian, and bladder cancers [9]. " - Cisplatin ld50 in mice

Cisplatin ld50 in mice

Cisplatin-induced immune modulation in ovarian cancer mouse …

WebSingle dose of cisplatin (16 mg/kg) in aging and young mice resulted in 100% mortality of 24-month-old female mice and 40% mortality of 4-8-week-old mice within 7 days after administration [148, 149]. Increased … WebJun 30, 1983 · The embryonic LD50 for mice was 5.24 mg/kg. An increase in the incidence of growth retardation or gross malformations was not discernable in the surviving fetuses with the number of dams used in this study. Cisplatin is highly embryolethal in rats and mice at dosages well below the adult therapeutic dosage in humans.

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WebThe LD 50 was 8.6 mg/kg for free cisplatin and 103.4 mg/kg for cisplatin-loaded nanoparticles, as shown in Table 3. Therefore, compared with free cisplatin, the nanopar- ticles loaded with...

WebMouse IP LD50 40 mg/kg No data available. Material Name: Cisplatin Injection Sodium chloride Molecular Formula: Rat Oral LD50 3000 mg/kg Mixture Mouse Oral LD50 4000 mg/kg Version: 1.0 Cisplatin Mannitol Molecular Weight: Rat Oral LD 50 13500 mg/kg … WebOct 16, 2024 · Similarly, we found that cisplatin could be safely dosed at 6 mg/kg, and that 1/3 mice lost more than 20% weight after 8 mg/kg, while …

WebThese human neoplastic cells are also more susceptible than peripheral blood mononuclear cells (PBMCs) toward the tested compounds. Using C57BL/6 mice an LD50 of 55mgkg(-1) was determined for complex (2), suggesting that this compound is almost four times less toxic than cisplatin (LD50=14.5mgkg(-1)). WebDec 23, 2024 · In humans, the volume of peritoneal fluid ranges from 50 to 75 ml ( 7 ), whereas in mice its volume ranges between 0.02 and 0.1 ml ( 8 ). In addition, the peritoneal fluid contains leukocytes and antibodies to fight off infections, and plasma proteins at concentration that is about 50% of what is found in plasma ( 9 ).

WebThe mice were sacrificed on the 35th day from the first injection. Estimation of Acute Toxicity of Polycisplatin. ICR mice (5 weeks old) weighing 20–23 g were subjected to a study to measure the lethal dose (LD 50) of Polycisplatin to compare with that of cisplatin. The mice were randomly divided into six groups with four mice each.

WebCisplatin was positive in a battery of in vitro and in vivo genotoxicity assays to detect mutagenic and clastogenic activity. Carcinogenicity Cisplatin has been shown to be carcinogenic in mice and rats. Secondary malignancies have been reported in cancer … how many fb accounts can i haveWebMouse IP LD50 40 mg/kg No data available. Material Name: Cisplatin Injection Sodium chloride Molecular Formula: Rat Oral LD50 3000 mg/kg Mixture Mouse Oral LD50 4000 mg/kg Version: 1.0 Cisplatin Mannitol Molecular Weight: Rat Oral LD 50 13500 mg/kg Mixture Rat Oral LD 50 25.8 mg/kg high waisted compression running pantsWebJun 12, 2024 · Effects of cisplatin (3.5 mg/kg at 72‐h intervals) on UM‐SCC‐22A (A) versus UM‐SCC‐47 (B)‐derived xenograft tumors grown in the flanks of SCID mice were measured at days 0 and 14 (n = 5–8 mice/group, and *P < 0.05 by unpaired Student's t‐test).After the measurement of tumor volumes, CerS1‐6 mRNAs were measured in extracted tumor … high waisted compression pants for womenWebCisplatin is rapidly and well absorbed systemically following intraperitoneal administration, resulting in 50-100% of the degree of systemic exposure compared with intravenous administration when comparable doses are given (McEvoy, 1995). 8.7.2 Distribution by route of exposure After intravenous administration cisplatin disappears from the plasma … high waisted compression running leggingsWebOct 6, 2014 · Synonyms Cisplatin; cis-DDP Recommended Use Laboratory chemicals. Uses advised against Food, drug, pesticide or biocidal product use. Details of the supplier of the safety data sheet Emergency Telephone Number For information US call: 001-800-ACROS-01 / Europe call: +32 14 57 52 11 Emergency Number US:001-201-796-7100 / … how many fbs teams are thereWebMar 15, 2016 · Cisplatin at 25 mg/kg in PBS (200 μl/animal) was administered by an intraperitoneal injection. Seventy-two hours after cisplatin injection, these mice were euthanized. Another cohort of mice received either 7 or 9 mg/kg cisplatin administered by an intraperitoneal injection once a week for 4 wk. high waisted compression thongWebSep 1, 2024 · The serum of nutlin-3a or cisplatin-treated mice was obtained 4 h after LPS injection. Tissues of nutlin-3a or cisplatin-treated mice were obtained 12 h after LPS injection. Survival of mice was monitored after an i.p. injection of LPS (60 mg/kg) or E. coli (1 × 10 8 CFU). high waisted compression tights black nike