Chunshan gui and oatp1b1

Author: oyur

August undefined, 2024

WebSep 16, 2009 · The liver-specific organic anion transporting polypeptides OATP1B1 and OATP1B3 are highly homologous and share numerous substrates. However, at low concentrations OATP1B1 shows substrate selectivity for estrone-3-sulfate. WebChunshan Gui Brett Wahlgren Gerald Lushington Bruno Hagenbuch Evidence shows that drug-drug interactions can occur at the level of drug transporters such as the organic anion transporting...

Cloning/Characterization of the Canine Organic Anion …

WebDec 24, 2024 · Taken together with our previous results 7 that the mutations of OATP1B1*5, *15 and CYP2C9*2, *3 significantly affect the transport and metabolism of glimepiride … WebJun 30, 2011 · Chunshan Gui et al. have confirmed that ursolic acid is a selective OATP1B3 and OATP1B1 inhibitor (Chunshan et al. 2010 ). Therefore, there may be an interaction between ursolic acid and rosuvastatin. A reasonable combination use of rosuvastatin and herbal medicines containing ursolic acid has important clinical value. dewalt 4 bank battery charger

Gly45 and Phe555 in Transmembrane Domains 1 and 10 …

WebIdentification, Ki determination and CoMFA analysis of nuclear receptor ligands as competitive inhibitors of OATP1B1-mediated estradiol-17β-glucuronide transport … WebChunshan Gui Organic anion transporting polypeptide 1B1 (OATP1B1) is a key hepatic uptake transporter whose inhibition could lead to adverse drug-drug and drug-food interactions. WebApr 1, 2010 · Author links open overlay panel Chunshan Gui a, Bruno Hagenbuch a b. Show more. Add to Mendeley. Share. Cite. ... (Hagenbuch and Gui, 2008, König et al., 2006). Mice and rats have only a single transporter in the OATP1B family that is the ortholog of human OATP1B1 and OATP1B3 which arose through gene duplication after … churchland elementary school nc

OATP1B3 (699G>A) and CYP2C9*2, *3 significantly …

Role of transmembrane domain 10 for the function of …

WebJianqing Ruan, and Chunshan Gui* Cite This: ACS Omega 2024, 6, 35844−35851 Read Online ... (OATP1B1), OATP1B3, OATP2B1, Na+/taurocholate cotransporting polypeptide (NTCP), organic cation transporter 1 (OCT1), and OAT2, have been investigated to see whether they are involved in the hepatic uptake of PSP. An in vitro cell-based study ... WebDec 16, 2024 · OATP1B1, OATP1B3, and OATP2B1, with OATP1B3 showing the highest transport eﬃciency. The Kmvalues for OATP1B1-, OATP1B3-, and OATP2B1-mediated PSP uptake were 11.3 ± 1.5, 7.0 ±1.5, and 5.1 ±1.0... churchland elementaryWebIdentification, Kidetermination and CoMFA analysis of nuclear receptor ligands as competitive inhibitors of OATP1B1-mediated estradiol-17β-glucuronide transport Chunshan Guia, Brett Wahlgrena, Gerald H. Lushingtonb, and Bruno Hagenbucha,c,* churchland elementary school portsmouth

"WebIn this study, we investigated the molecular mechanism for this substrate selectivity of OATP1B1 by constructing OATP1B1/1B3 chimeric transporters and by site-directed … " - Chunshan gui and oatp1b1

Chunshan gui and oatp1b1

Identification, Ki determination and CoMFA analysis of nuclear …

WebChunshan Gui a and Bruno Hagenbuch a, b Author ... nothing is known about their OATP1B1/1B3 ortholog. Therefore, we cloned and characterized the first canine organic … WebChunshan Gui, a Brett Wahlgren, a Gerald H. Lushington, b and Bruno Hagenbuch a, c, * ... Inhibition of OATP1B1-mediated estradiol-17β-glucuronide uptake by 37 nuclear …

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WebAug 9, 2008 · Human organic anion transporting polypeptides (OATP) 1B1 and 1B3 are multispecific transporters that mediate uptake of amphipathic organic compounds into hepatocytes. The two OATPs contain 12 transmembrane domains (TMs) and share 80% amino acid sequence identity. WebAug 9, 2008 · Europe PMC is an archive of life sciences journal literature. Search life-sciences literature (Over 39 million articles, preprints and more)

WebNov 1, 2009 · Search worldwide, life-sciences literature Search. Advanced Search WebAbstract: The two organic anion transporting polypeptides (OATPs) 1B1 and 1B3 are expressed at the sinusoidal membrane of hepatocytes. They have a broad and overlapping substrate specificity and transport many endobiotics and drugs.

WebChunshan Gui Brett Wahlgren Gerald Lushington Bruno Hagenbuch Evidence shows that drug-drug interactions can occur at the level of drug transporters such as the organic anion transporting... WebThis type of analysis has been previously successfully used to determine the type of interaction of OATP1B1 with a wide range of physiological substrates and fibrates (Gui et al., 2009; Yamazaki ...

WebSep 2, 2008 · Three-dimensional model of the OATP1B3/CCK-8 complex. A side view (A) and a view from the intracellular side (B) are presented. Helical segments of the protein are shown in cylinders; the three residues Y537, S545 and T550 in TM10 are shown in ball-and-stick and in orange; CCK-8 is shown in ball-and-stick and in purple.

WebJan 1, 2024 · Chunshan Gui Organic anion transporting polypeptide 1B1 (OATP1B1) is a key hepatic uptake transporter whose inhibition could lead to adverse drug-drug and drug-food interactions. churchland elementary vaWebChunshan Gui - College of Pharmaceutical Sciences, Soochow University, 199 Renai Road, Suzhou Industrial Park, ... polypeptides OATP1B1 and OATP1B3 are highly … churchland facebookWebMay 29, 2014 · Chunshan Gui Authors' Affiliations: ... Transport of paclitaxel, docetaxel, and cabazitaxel was studied in vitro using various cell lines transfected with OATP1B1, OATP1B3, or the rodent equivalent OATP1B2. Pharmacokinetic studies were done in wild-type and OATP1B2-knockout mice in the presence or absence of polysorbate 80 (PS80) … dewalt 4 amp batteryWebMar 1, 2010 · Comparison of OATP1B1- and OATP1B3-mediated transport of fluorescent substrates. Uptake was measured with 1 µM of the indicated fluorescent compounds on 24-well plates for 30 min. Values are means ± SE of two combined independent experiments each performed with triplicate determinations. churchland eliminative materialism premisesWebAug 6, 2024 · A number of drug-drug and drug-food interactions have been associated with OATP1B1 and 1B3, affecting the pharmacokinetics and pharmacodynamics of their … dewalt 4 bay chargerWebWe have used OATP1B1- or OATP1B3-expressing Chinese Hamster Ovary cells on 96-well plates and determined uptake of fluorescein-methotrexate (FMTX). We validated the assay with known inhibitors and screened the well characterized Prestwick library of 1120 drugs. churchland elementary school portsmouth vaWebChunshan Gui1, Amanda Obaidat1, Rathnam Chaguturu2,3 and Bruno Hagenbuch*,1,2 ... hibitors for OATP1B1 and OATP1B3. We have used OATP1B1- or OATP1B3-expressing Chinese Hamster Ovary cells ... 2010, Volume 4 Gui et al. used this assay to screen the Prestwick library for modulators (inhibitors or stimulators) and confirmed several hits by dewalt 4 bay battery charger