Bub1 proliferation

Author: dmcu

August undefined, 2024

To further explore the relationship between BUB1 and STAT3 in BCa, we examined whether BUB1 regulates the activation of STAT3 by phosphorylation. First, an in vitro kinase assay was performed in 5637 cells. We incubated purified recombinant human BUB1 protein with purified STAT3 protein and H2A histone … See more The functions of BUB1 during the progression and carcinogenesis of BCa are not fully understood. Comprehensive analysis of the … See more The BUB1 kinase protein contains multiple functional domains (Fig. 3A). Gang et al.’s SALIC proteomic data showed that BUB1 interacted with STAT [27]. To observe whether native BUB1 … See more To understand the biological significance of BUB1-mediated phosphorylation and the effects of BUB1 on the occurrence and progression of BCa, we investigated the transcriptomes of … See more To confirm this conclusion, we performed qRT–PCR by knocking down BUB1 with siRNA, and the results showed that the transcriptional activity of STAT3 was reduced significantly and that the expression of STAT3 … See more WebBUB1 (BUB1A, BUB1L, hBUB1) protein expression summary. Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly c heckpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization …

BUB1 promotes proliferation of liver cancer cells by

WebBub1 is an evolutionarily conserved mitotic checkpoint control protein that is present in diverse organisms including yeast and humans. Bub1 is a serine/threonine protein kinase and is required for recruitment of Mad1, Mad2, Bub3, and CENP-E to kinetochores. WebApr 4, 2024 · BUB1 and BUBR1 inhibition decreases proliferation and shows radiosensitizing effects on pediatric glioblastoma cells Bub1-mediated H2A … meyer b\u0026b comfort texas

BUB1 and BUBR1 inhibition decreases proliferation and colony …

WebFeb 13, 2012 · Anti-Bub1 antibody [EPR18947] (ab195268) Research with confidence – consistent and reproducible results with every batch Long-term and scalable supply – … WebAug 5, 2024 · The process of cell division plays a vital role in cancer progression. Cell proliferation and error-free chromosomes segregation during mitosis are central events in life cycle. Mistakes during cell division generate changes in chromosome content and alter the balances of chromosomes number. Any defects in expression of TIF1 family proteins, … WebSep 27, 2024 · The expression of bub1 was found to be able to reduce the immunosuppressive effect of these cancers ( 30 – 33 ). bub1 expression was increased in human bladder cancer (BCa), and bub1 kinase drives the progression and proliferation of BCa by regulating the transcriptional activation of STAT3 signaling ( 34 ). meyer building concepts

Bub1 MGI Mouse Gene Detail - MGI:1100510 - BUB1, mitotic …

Inhibition of BUB1 suppresses tumorigenesis of osteosarcoma via ...

WebDec 15, 2024 · Bub1 has a Bub3-binding domain through which Bub1 is localized to kinetochores . The Bub1 central region acts as a scaffold for Bub1-mediated localization … WebBUB1 and BUBR1 are cell cycle-independent binding partners of BUB3 and are recruited to unattached kinetochores through BUB3. BUBR1:BUB3 may have two pools at KNL1, one dependent on BUB1 and the other independent of BUB1. KNL1 also recruits the Rod-ZW10-Zwilch (RZZ complex) in a BUB1-dependent manner (Zhang et al., 2015 ). meyer buildings dorchester wiWebBUB1 and BUBR1 inhibition decreases proliferation and shows radiosensitizing effects on pediatric GBM cells, which could improve treatment strategies for this devastating tumor. … meyer burger 385 wp white hjt

"WebJan 15, 2024 · βArr1 or βArr2 are regulated in breast tumours To determine the clinical significance of the two βArrs we explored the expression profiles of these two genes in TCGA breast tissue data set 35. The... " - Bub1 proliferation

Bub1 proliferation

Zombies Never Die: The Double Life Bub1 Lives in Mitosis

WebNov 2, 2015 · Bub1 (Budding uninhibited by benzimidazoles 1) is a mitotic checkpoint serine/threonine kinase that plays an important role in chromosome segregation. Bub1 expression is correlated with a poor... WebFeb 1, 2006 · The proliferation signature is now commonly associated with the expression of a core set of genes ( MYBL2, BUB1 and polo-like kinase 1 ( PLK1 )), along with other cell-cycle-regulated genes...

Did you know?

WebDec 1, 2024 · Finally, BUB1 also enhanced NFATC2- and LHX1-induced BCa cell proliferation mediated by STAT3. A pharmacological inhibitor of BUB1 (2OH-BNPP1) … WebMar 5, 2024 · BUB1 may promote proliferation of hepatocellular carcinoma cells by activating phosphorylation of SMAD2 [74]. Not surprisingly, among them, CDC20, CCNA2, and BUB1 are all associated with...

WebDec 22, 2024 · BUB1 is a prototype member of a family of genes, some of which encode proteins that bind to the kinetochore and all of which are required for a normal mitotic delay in response to spindle disruption. They cloned the human homolog of BUB1 and determined the complete coding sequence. WebAug 1, 2024 · Furthermore, BUB1 overexpression was closely associated with the poor clinical outcomes of patients with OS. Inhibition of BUB1 markedly suppressed cell …

WebBub1 is a serine/threonine protein kinase first identified in genetic screens of Saccharomyces cerevisiae. [7] The protein is bound to kinetochores and plays a key role in the establishment of the mitotic spindle checkpoint and chromosome congression. WebJan 4, 2013 · Mitotic checkpoint is a fundamental mechanism involved in fidelity mitotic chromosome segregation, and its alteration results in progression of human malignancies. In this study, we examined expression profiles of seven mitotic checkpoint genes in 20 breast carcinomas using microarray analysis. Results demonstrated that BUB1 expression level …

WebNov 11, 2024 · One upregulated gene in lipedema ADSCs, Bub1, encodes a cell-cycle regulator, central to the kinetochore complex, which regulates several histone proteins …

WebMay 22, 2024 · Additionally, the GEPIA database showed that the CDK1, CCNB1, CDC20, BUB1, MAD2L1, MCM3, BUB1B, MCM2, and RFC4 were associated with the poor survival of HCC patients. UALCAN, Oncomine, and HPA databases and qRT-PCR confirmed that these genes were highly expressed in HCC tissues. meyer buildings indianaWebBub1 Gene Detail Summary Symbol Bub1 Name BUB1, mitotic checkpoint serine/threonine kinase Synonyms Bub1a, D2Xrf87 Feature Type protein coding gene IDs MGI:1100510 NCBI Gene: 12235 Alliance gene page Transcription Start Sites 2 TSS Location & Maps more Sequence Map Chr2:127643036-127673785 bp, - strand From … meyer b\\u0026b comfort txWebConsidering the critical roles Bub1 plays in mitosis as discussed above, it is hardly to question its essentiality in higher eukaryotes. Indeed, in mouse studies, knockout of BUB1 resulted in embryonic lethality after day E3.5. Late inactivation on day E10.5 quickly shut down further development. how to buy shower head how to buy shower curtain rodWebImmunohistochemistry, qRT-PCR, and Western blot were employed to detect BUB1 and transforming growth factor-beta (TGFβ/Smad) signaling-related proteins expression in … meyer burger 370 w glas/glas bifazialWebSep 23, 2009 · Background Bub1 is a component of the spindle assembly checkpoint, a surveillance mechanism that maintains chromosome stability during M-phase. Bub1 is essential during the early stages of embryogenesis, with homozygous BUB1-null mice dying shortly after day E3.5. Bub1 is also required later during embryogenesis; inactivation of … meyer burger actionsWebOct 1, 2024 · BOS172722 (CCT289346) is a highly potent, selective, and orally bioavailable inhibitor of spindle assembly checkpoint kinase MPS1. BOS172722 treatment alone induces significant sensitization to death, particularly in highly proliferative triple-negative breast cancer (TNBC) cell lines with compromised spindle assembly checkpoint activity. meyer burger black spec sheet